I work on natural and artificial intelligence, and apply the results to the design and engineering of versatile AI tools and deployment of human-centred applications. Medicine is the model for my research; a challenging domain in which to understand human and machine thinking. Synergy between basic research and practical applications is key to achieving sound scientific foundations and safe engineering in AI (see Artificial Intelligence in Hazardous Applications, J Fox S Das, MIT Press, 2000). I have co-founded a number of AI startups including Expertech, InferMed and Deontics, and OpenClinical, a social enterprise aimed at improving patient care through innovative AI and knowledge engineering techniques. OpenClinical has recently been spun-in to Oxford University Innovation's portfolio of not-for-profit companies see www.openclinical.net. For an overview of our approach, technologies and applications see "Cognitive systems at the point of care: the CREDO program" (J Biomedical Informatics, 2017 http://www.sciencedirect.com/science/article/pii/S1532046417300333). "[this] work represents a breakthrough ... a true advance towards cognitively grounded computing – showing how to build a bridge between cognitive architectures and the design of clinical services, taking account also of recent developments in ontology and knowledge representation." B Smith, Director of the National Center for Ontological Research at the University of Buffalo (2017). Publications etc, can be found at ResearchGate: https://www.researchgate.net/profile/John_Fox5?ev=hdr_xprf I am also an experienced consultant in AI, knowledge engineering, cognitive systems and medical informatics.